Total synthesis of (.+-.)-asteltoxin

SL Schreiber, K Satake

文献索引：Schreiber; Satake Journal of the American Chemical Society, 1984 , vol. 106, # 15 p. 4186 - 4188

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被引用次数: 88

摘要

Abstract: A convergent synthesis of (&)-asteltoxin has been achieved in 16 steps (3.0% overall yield) from 3, 4-dimethylfuran. The attachment of the triene pyrone side chain to the bis (tetrahydr0furan) skeleton proceeds by way of the addition of the Corey equivalent to anion 3 to the aldehyde 2 and a subsequent aldol condensation-dehydration reaction of pyrone 4.