Tetrahedron Letters

Enantioselective syntheses of homophenylalanine derivatives via nitrone 1, 3-dipolar cycloaddition reactions with styrenes

A Long, SW Baldwin

文献索引：Long, Alan; Baldwin, Steven W. Tetrahedron Letters, 2001 , vol. 42, # 32 p. 5343 - 5345

全文：HTML全文

被引用次数: 38

摘要

A new two-step route to derivatives of homophenylalanine is presented. Cycloaddition of a cyclic nitrone glycine template with various styrene derivatives affords good yields of 5- substituted cycloadducts. One-step hydrogenolysis (three bonds) then affords the optically pure α-amino acids related to homophenylalanine.