Helvetica Chimica Acta

Design and Synthesis of Some Novel 2, 3, 4, 5??Tetrahydro??1H??pyrido [4, 3??b] indoles as Potential c??Met Inhibitors

L Ye, Y Tian, Z Li, J Zhang, S Wu

文献索引：Ye, Lianbao; Tian, Yuanxin; Li, Zhonghuang; Zhang, Jiajie; Wu, Shuguang Helvetica Chimica Acta, 2012 , vol. 95, # 2 p. 320 - 326

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被引用次数: 7

摘要

Abstract Since deregulation of the tyrosine-kinase receptor c-Met is implicated in several human cancers and is an attractive target for small-molecule-drug discovery, we report herein the synthesis of 2, 3, 4, 5-tetrahydro-8-[1-(quinolin-6-ylmethyl)-1H-1, 2, 3-triazolo [4, 5- b] pyrazin-6-yl]-1H-pyrido [4, 3-b] indoles 4a–4c and 2, 3, 4, 5-tetrahydro-8-[3-(quinolin-6- ylmethyl)-1, 2, 4-triazolo [4, 3-b] pyridazin-6-yl]-1H-pyrido [4, 3-b] indoles 5a–5c. These ...