Inhibition of Tpl2 kinase and TNFα production with quinoline-3-carbonitriles for the treatment of rheumatoid arthritis

Y Hu, N Green, LK Gavrin, K Janz, N Kaila…

文献索引：Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 23 p. 6067 - 6072

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被引用次数: 57

摘要

... Bioorganic & Medicinal Chemistry Letters. Volume 16, Issue 23, 1 December 2006, Pages 6067–6072. ... The more readily accessible quinoline-3-carbonitrile chemistry 7 allowed us to better explore SAR at R 1 , R 2 , headpiece and tailpiece of the molecule (Scheme 1). ...