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Synthesis and Radioiodination of Some 9??Aminoacridine Derivatives

…, H Lundqvist, V Tolmachev, S Sjöberg…

文献索引:Ghirmai, Senait; Mume, Eskender; Henssen, Cecile; Ghaneolhusseini, Hadi; Lundqvist, Hans; Tolmachev, Vladimir; Sjoeberg, Stefan; Orlova, Anna European Journal of Organic Chemistry, 2004 , # 17 p. 3719 - 3725

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被引用次数: 7

摘要

Abstract Derivatives of 9-aminoacridine, namely N-[ψ-(acridin-9-ylamino) alkyl]-3- (trimethylstannyl) benzamides (1), where the alkyl group is propyl (1a) and octyl (1b), and 2- (acridin-9-ylamino)-3-(4-hydroxyphenyl) propionic acid (2), have been synthesized with the aim to use them as precursors in the syntheses of radiolabeled DNA intercalators for biological experiments. It was observed that compounds 1a and 1b can exist in two ...