Selective inhibition of bovine plasma amine oxidase by homopropargylamine, a new inactivator motif

C Qiao, HB Jeon, LM Sayre

文献索引：Qiao, Chunhua; Jeon, Heung-Bae; Sayre, Lawrence M. Journal of the American Chemical Society, 2004 , vol. 126, # 25 p. 8038 - 8045

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被引用次数: 23

摘要

Propargylic and activated allylic amines are known to inactivate the quinone-dependent plasma amine oxidases, possibly through active-site modification by the α, β-unsaturated aldehyde turnover products. Although homopropargylamine (1-amino-3-butyne, 1) is a nonobvious candidate as a mechanism-based inhibitor, 1 was found to be an unusually potent time-and concentration-dependent irreversible inactivator of bovine plasma amine ...