Abstract A general method for the liquid-phase syntheses of isoxazoles and isoxazolines through a 1, 3-dipolar cycloaddition is described. The poly (ethylene glycol)(PEG)-supported alkyne 2 or alkene 6 reacted with nitrile oxides generated in situ from aldoximes 3, followed by cleavage from the PEG, to give isoxazoles or isoxazolines in good yield and purity.
![(3-苯并[1,3]二氧代-5-异噁唑-5-基)-甲醇结构式](https://image.chemsrc.com/caspic/327/438565-34-5.png)