Synthesis of 5, 6-dichloroindan-1-acids and their tetrazolyl derivatives as analgesic and anti-inflammatory agents

…, A Kalam Azad Chowdhury, J Kumar Kundu…

文献索引：Pal, Rajib Kumar; Yasmin, Hasina; Nahar, Lutfun; Datta, Bidyut Kanti; Kundu, Joydeb Kumar; Bachar, Sitesh Chandra; Chowdhury, Abul Kalam Azad; Sarker, Satyajit Dey Medicinal Chemistry, 2012 , vol. 8, # 5 p. 874 - 882,9

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被引用次数: 6

摘要

Indan derivatives, namely, 5-(5', 6'-dichloroindan-1'-yl)-tetrazole (12a) and 5-(5', 6'- dichloroindan-1'-yl)-methyltetrazole (12b), were synthesized conveniently from 5, 6- dichloroindan-1-carboxylic acid (9a) and 5, 6-dichloroindan-1-acetic acid (9b), respectively, as potential analgesic and anti-inflammatory agents. The analgesic and anti-inflammatory properties of 9a, 9b, 12a and 12b were evaluated by the acetic acid induced writhing in ...