Chemistry Letters

1-O-Palmityl-D-glucuronate endows liposomes with long half-life in vivo.

Y Namba, T Sakakibara, M Masada, F Ito, N Oku

文献索引：Namba, Yukihiro; Sakakibara, Toshiyuki; Masada, Mikio; Ito, Fumiaki; Oku, Naoto Chemistry Letters, 1989 , p. 2145 - 2148

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被引用次数: 17

摘要

More liposomes containing 1-O-palmityl-D-glucuronic acid (PGA), a synthetic glycolipid, bound to macrophages than those containing phosphatidylglycerol did in vitro; however, PGA-liposomes circulated longer in vivo. PGA-liposomes did not aggregate in the presence of serum, but liposomes containing 1-O-palmityl-D-glucose or myristic acid aggregated rapidly, suggesting that both carbohydrate and carboxyl group of PGA are important for ...