Synthesis and antibacterial activity of 6-O-(heteroaryl-isoxazolyl) propynyl 2-fluoro ketolides

…, Y Shimazaki, A Manaka, T Tanikawa, K Suzuki…

文献索引：Sugimoto, Tomohiro; Shimazaki, Yoichi; Manaka, Akira; Tanikawa, Tetsuya; Suzuki, Keiko; Nanaumi, Kayoko; Kaneda, Yoshie; Yamasaki, Yukiko; Sugiyama, Hiroyuki Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 17 p. 5739 - 5743

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被引用次数: 4

摘要

Macrolide antibiotics are widely prescribed for the treatment of respiratory tract infections; however, the increasing prevalence of macrolide-resistant pathogens is a public health concern. Therefore, the development of new macrolide derivatives with activities against resistant pathogens is urgently needed. A series of novel 6-O-(heteroaryl-isoxazolyl) propynyl 2-fluoro ketolides has been synthesized from erythromycin A. These compounds ...