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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Tetrahedron

Reactions with indole derivatives-LV.: An enantiodivergent route to both vincamine enantiomers

K Hakam, M Thielmann, T Thielmann, E Winterfeldt

文献索引：Hakam, Khalida; Thielmann, Marion; Thielmann, Thomas; Winterfeldt, Ekkehard Tetrahedron, 1987 , vol. 43, # 9 p. 2035 - 2044

全文：HTML全文

被引用次数: 53

摘要

Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... The enantioselective synthesis of the tetracyclic lactam is reported which by enantiodivergent techniques is converted into (+)- as well as (-)-vincamine via the corresponding eburnamonine enantiomers. ... K. Oshima, K. Takai, Y. Hotta, and H. Nozaki, Tetrahedron Lett., 1978, 2417.

ethyl 2-((3aR,4S)-4-ethyl-4-(2-methoxy-2-oxoethyl)-6-oxo-3a,4,5,6-tetrahydro-1H-indolo[3,2,1-de][1,5]naphthyridin-3(2H)-yl)acetate结构式

ethyl 2-((3aR,4...

~%

(41'S,13a'R)-13a'-ethyl-3',41',5',6',13',13a'-hexahydrospiro[[1,3]dithiane-2,2'-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridin]-12'(1'H)-one结构式

(41'S,13a'R)-13...

未登录结构式

~%

(41'S,13a'R)-13a'-ethyl-3',41',5',6',13',13a'-hexahydrospiro[[1,3]dithiane-2,2'-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridin]-12'(1'H)-one结构式

(41'S,13a'R)-13...

2-((1S,11bS)-1-ethyl-3-oxo-2,3,5,6,11,11b-hexahydro-1H-indolizino[8,7-b]indol-1-yl)acetic acid结构式

2-((1S,11bS)-1-...

~%

(41'S,13a'R)-13a'-ethyl-3',41',5',6',13',13a'-hexahydrospiro[[1,3]dithiane-2,2'-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridin]-12'(1'H)-one结构式

(41'S,13a'R)-13...

ent-18-oxo-eburnamonine结构式

ent-18-oxo-ebur...

~%

eburnamonine-17α-xanthogenate结构式

eburnamonine-17...

ethyl 2-((3aR,4S)-4-ethyl-4-(2-methoxy-2-oxoethyl)-6-oxo-3a,4,5,6-tetrahydro-1H-indolo[3,2,1-de][1,5]naphthyridin-3(2H)-yl)acetate结构式

ethyl 2-((3aR,4...

~%

eburnamonine-17α-xanthogenate结构式

eburnamonine-17...

未登录结构式

~%

eburnamonine-17α-xanthogenate结构式

eburnamonine-17...

2-((1S,11bS)-1-ethyl-3-oxo-2,3,5,6,11,11b-hexahydro-1H-indolizino[8,7-b]indol-1-yl)acetic acid结构式

2-((1S,11bS)-1-...

~%

eburnamonine-17α-xanthogenate结构式

eburnamonine-17...

ent-18-oxo-eburnamonine结构式

ent-18-oxo-ebur...

~94%

(41S,13aS)-13a-ethyl-2-hydroxy-2,3,5,6,13,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridin-12(41H)-one结构式

(41S,13aS)-13a-...

ethyl 2-((3aR,4S)-4-ethyl-4-(2-methoxy-2-oxoethyl)-6-oxo-3a,4,5,6-tetrahydro-1H-indolo[3,2,1-de][1,5]naphthyridin-3(2H)-yl)acetate结构式

ethyl 2-((3aR,4...

~%

(41S,13aS)-13a-ethyl-2-hydroxy-2,3,5,6,13,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridin-12(41H)-one结构式

(41S,13aS)-13a-...

未登录结构式

~%

(41S,13aS)-13a-ethyl-2-hydroxy-2,3,5,6,13,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridin-12(41H)-one结构式

(41S,13aS)-13a-...

2-((1S,11bS)-1-ethyl-3-oxo-2,3,5,6,11,11b-hexahydro-1H-indolizino[8,7-b]indol-1-yl)acetic acid结构式

2-((1S,11bS)-1-...

~%

(41S,13aS)-13a-ethyl-2-hydroxy-2,3,5,6,13,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridin-12(41H)-one结构式

(41S,13aS)-13a-...

未登录结构式

~%

ent-18-oxo-eburnamonine结构式

ent-18-oxo-ebur...

2-((1S,11bS)-1-ethyl-3-oxo-2,3,5,6,11,11b-hexahydro-1H-indolizino[8,7-b]indol-1-yl)acetic acid结构式

2-((1S,11bS)-1-...

~%

ent-18-oxo-eburnamonine结构式

ent-18-oxo-ebur...

未登录结构式

~%

ethyl 2-((3aR,4S)-4-ethyl-4-(2-methoxy-2-oxoethyl)-6-oxo-3a,4,5,6-tetrahydro-1H-indolo[3,2,1-de][1,5]naphthyridin-3(2H)-yl)acetate结构式

ethyl 2-((3aR,4...

2-((1S,11bS)-1-ethyl-3-oxo-2,3,5,6,11,11b-hexahydro-1H-indolizino[8,7-b]indol-1-yl)acetic acid结构式

2-((1S,11bS)-1-...

~%

ethyl 2-((3aR,4S)-4-ethyl-4-(2-methoxy-2-oxoethyl)-6-oxo-3a,4,5,6-tetrahydro-1H-indolo[3,2,1-de][1,5]naphthyridin-3(2H)-yl)acetate结构式

ethyl 2-((3aR,4...