Macromolecular self-assembly of diketopiperazine tetrapeptides
RJ Bergeron, O Phanstiel IV, GW Yao…
文献索引:Bergeron, Raymond J.; Phanstiel IV, Otto; Yao, Guo Wei; Milstein, Sam; Weimar, William R. Journal of the American Chemical Society, 1994 , vol. 116, # 19 p. 8479 - 8484
Abstract: Basic solutions of tetrapeptides derived from L-aspartic acid diketopiperazines are shown to form microcapsules when acidified to pH 2.4. An initial structure-activity study clearly demonstrates that a very delicate balance exists between the tetrapeptides' structure and their ability to self-assemble. Scanning electron micrographs confirm that microcapsules and not solid microspheres are formed.