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Antiallergy agents. 1. Substituted 1, 8-naphthyridin-2 (1H)-ones as inhibitors of SRS-A release

…, JJ Kaminski, WC Tom, JF Lee, SC Wong…

文献索引:Sherlock, Margaret H.; Kaminski, James J.; Tom, Wing C.; Lee, Joe F.; Wong, Shing-Chun; et al. Journal of Medicinal Chemistry, 1988 ,  vol. 31,  # 11  p. 2108 - 2121

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被引用次数: 69

摘要

Scheme I). The required nicotinic acids and esters described in Table I, and the substituted amines described in the experimental section were either commercially available or their method of preparation has been described previo~ sly.~*-~~ The substituted pyridines (3) and congeners described in Table I1 were prepared by the procedures described by Kermack and Weatherhead24 or Nantka-N amir~ ky,~~ respectively. Following the ...