Inhibition of γ-secretase by the CK1 inhibitor IC261 does not depend on CK1δ

N Höttecke, M Liebeck, K Baumann…

文献索引：Bioorganic and Medicinal Chemistry Letters, , vol. 20, # 9 p. 2958 - 2963

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被引用次数: 11

摘要

... Bioorganic & Medicinal Chemistry Letters. ... We chose the 5-cloro substituted oxoindole as backbone as it is supposed to show enhanced metabolic stability, 10 which is commonly used in medicinal chemistry, for example, Pfizer's Carprofen (4). All compounds were tested in ...