Effects of cytoprotective antioxidants on lymphocytes from representative mitochondrial neurodegenerative diseases

…, OM Khdour, VC Collin, S Dey, J Jaruvangsanti…

文献索引：Goldschmidt, Ruth; Arce, Pablo M.; Khdour, Omar M.; Collin, Valerie C.; Dey, Sriloy; Jaruvangsanti, Jennifer; Fash, David M.; Hecht, Sidney M. Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 4 p. 969 - 978

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被引用次数: 14

摘要

Two new aza analogues of the neuroprotective agent idebenone have been synthesized and characterized. Their antioxidant activity, and ability to augment ATP levels have been evaluated in several different cell lines having suboptimal mitochondrial function. Both compounds were found to be good ROS scavengers, and to protect the cells from oxidative stress induced by glutathione depletion. The compounds were more effective than ...