Summary 1. Several series of local anesthetics of the procaine type are described. Modifications of the general formula, NHZC~ HL! OO-X-NR~ R~, were synthesized in which (a) the alkyl groups on the nitrogen were varied while several nuclei of the type NHzC6H4COO-X-were held constant;(b) the X was a forked residue with only two carbons between the oxygen and nitrogen;(c) the X was a straight-chain residue consisting of 2, 3, ...
