An efficient chiral total synthesis of (+)-nojirimycin (1) and (+)-1-deoxynojirimycin (2) has been achieved in optically pure form via the common intermediate 11 derived from the nonsugar chiral pool. The monosilyl derivative 4 of 2, 3-0-isopropylidene-~-threitol (3) was converted to the (E)-allyl alcohol 8, which upon asymmetric epoxidation provided the syn epoxide 9. Regio-and stereoselective epoxide opening reaction of 9 followed by ...
![[(4S,5S)-5-({[(tert-butyl)(dimethyl)silyl]oxy}methyl)-2,2-dimethyl-1,3-dioxolan-4-yl]methanol结构式](https://image.chemsrc.com/caspic/397/108817-96-5.png)
