Carbostyril derivatives having potent. beta.-adrenergic agonist properties
J Milecki, SP Baker, KM Standifer, T Ishizu…
文献索引：Milecki, Jan; Baker, Stephen P.; Standifer, Kelly M.; Ishizu, Takashi; Chida, Yasuhiro; et al. Journal of Medicinal Chemistry, 1987 , vol. 30, # 9 p. 1563 - 1566
Results Chemistry. The method of synthesis of the carbostyril derivatives (Scheme I) was based on Goodman's approach to the synthesis of catecholamine derivatives. 11J6 Commercial 8-hydroxyquinoline was converted by aqueous formaldehyde-hydrogen chloride to the hydrochloride of 5-(chloromethyl)-8-hydroxyquinoline, which, by treatment with aqueous ammonia, yielded B-hydroxy-5-(hydroxymethy1) quinoline (1). Both of these ...
