Synthesis of 1-acylamino-1-(trimethylsiloxy) alkanes by trimethylsilyl trifluoromethanesulfonate-catalysed addition of bis (trimethylsilyl) amides to aldehydes
AP Johnson, RWA Luke, RW Steele…
文献索引：Johnson, A. Peter; Luke, Richard W. A.; Steele, Robert W.; Boa, Andrew N. Journal of the Chemical Society - Perkin Transactions 1, 1996 , # 9 p. 883 - 893
Bis (trimethylsilyl) formamide reacts with aldehydes in refluxing chloroform, or at room temperature with catalysis by trimethylsilyl trifluoromethanesulfonate, to give 1-acylamino-1- (trimethylsiloxy) alkanes; similar results are obtained with other bis (trimethylsilyl) amides, but surprisingly not with bis (trimethylsilyl) acetamide, and addition of bis (trimethylsilyl) formamide to ketones and acetals can also be accomplished using TMS triflate as catalyst.
