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Medicinal Chemistry Research

Synthesis and structure–activity relationships of aliphatic isothiocyanate analogs as antibiotic agents

D Li, Y Shu, P Li, W Zhang, H Ni, Y Cao

文献索引:Li, Deguang; Shu, Yanan; Li, Pingliang; Zhang, Wenbing; Ni, Hanwen; Cao, Yongsong Medicinal Chemistry Research, 2013 , vol. 22, # 7 p. 3119 - 3125

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被引用次数: 3

摘要

Abstract Isothiocyanates (ITCs) are one of the many classes of breakdown products of glucosinolates found in plants and exhibit biologic activity against various pathogens. In this work, aliphatic isothiocyanates were prepared and the antimicrobial activities against plant pathogenic fungi and bacteria were tested to understand the structure–activity relationships. The results indicated that longer-chain derivatives exert a steric inhibition on toxicity of ...