Synthesis and biological activity of novel quaternary ammonium derivatives of alkylglycerols as potent inhibitors of protein kinase C

…, KL Meyer, S Morris-Natschke, KS Ishaq…

文献索引：Marasco Jr.; Piantadosi; Meyer; Morris-Natschke; Ishaq; Small; Daniel Journal of Medicinal Chemistry, 1990 ,  vol. 33,  # 3  p. 985 - 992

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被引用次数: 57

摘要

Alkylglycerols such as rac-l-0-octadecyl-2-O-methylglycerophosphochwholiie (Et-l&OMe) have shown an inhibitory effect on the metastasis and growth of various cancer cell lines. Alkyl phospholipids have been shown to accumulate at the surface in several cell lines, ...