Synthesis of novel cholesterol-based cationic lipids for gene delivery

…, KO Doh, JH Nam, H Kang, JG Park, IJ Moon…

文献索引：Kim, Bieong-Kil; Doh, Kyung-Oh; Nam, Joo Hyeung; Kang, Hyungu; Park, Jong-Gu; Moon, Ik-Jae; Seu, Young-Bae Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 11 p. 2986 - 2989

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被引用次数: 18

摘要

The new cholesterol-based cationic lipids B, C, and D with an ether linked spacer were synthesized by using aminopropyl chain extension with acrylonitrile. The cholesterol-based cationic lipid A with carbamoyl linkage were also synthesized in order to compare the difference in transfection efficiency of the two linkage types. To this end, GFP expression of these cationic lipids was confirmed respectively.