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An unusual ring expansion from the Zav'yalov pyrrole synthesis: formation of oxacino [2, 3-c] pyrroles

CD Gabbutt, JD Hepworth, B áMark Heron…

文献索引:Gabbutt, Christopher D.; Hepworth, John D.; Heron, B. Mark; Elsegood, Mark R. J.; Clegg, William Chemical Communications, 1999 ,  # 3  p. 289 - 290

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摘要

Enamino acids 2 and 5 undergo a facile cyclisation to afford the pyrrole 3 and isoindole 6 ring systems; a novel two atom ring expansion ensues when derivatives 5b, d are subjected to the cyclisation conditions, resulting in the formation of the new oxacino [2, 3-c] pyrrole ...