Tetrahedron

Partial synthesis of major human metabolites of docetaxel

A Commerçon, JD Bourzat, D Bézard, M Vuilhorgne

文献索引：Commercon, Alain; Bourzat, Jean-Dominique; Bezard, Daniel; Vuilhorgne, Marc Tetrahedron, 1994 ,  vol. 50,  # 34  p. 10289 - 10298

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被引用次数: 22

摘要

The structures and synthesis of the four major human metabolites of docetaxel are reported. These metabolites, ie compounds 3, 4ab and 5, are side-chain oxidation derivatives. They were prepared by partial synthesis from the previously described amino-taxoid 8 using mixed-carbonates as acylation reagents. In vitro biological activities are detailed.