Conformationally constrained analogues of diacylglycerol. 29. Cells sort diacylglycerol-lactone chemical zip codes to produce diverse and selective biological …

…, RJ Surawski, PM Blumberg, VE Marquez

文献索引：Choi, Yongseok; Pu, Yongmei; Peach, Megan L.; Kang, Ji-Hye; Lewin, Nancy E.; Sigano, Dina M.; Garfield, Susan H.; Blumberg, Peter M.; Marquez, Victor E. Journal of Medicinal Chemistry, 2007 , vol. 50, # 15 p. 3465 - 3481

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被引用次数: 29

摘要

Diacylglycerol-lactone (DAG-lactone) libraries generated by a solid-phase approach using IRORI technology produced a variety of unique biological activities. Subtle differences in chemical diversity in two areas of the molecule, the combination of which generates what we have termed “chemical zip codes”, are able to transform a relatively small chemical space into a larger universe of biological activities, as membrane-containing organelles within ...