Synthesis of tetrahydroquinolines, hexahydrobenzoindolizines and an aryl phosphonate linker for the generation of catalytic antibodies

C González-Bello, C Abell, FJ Leeper

文献索引：Gonzalez-Bello, Concepcion; Abell, Chris; Leeper, Finian J. Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 7 p. 1017 - 1024

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被引用次数: 2

摘要

Syntheses of 6-methoxy-1-methyl-1, 2, 3, 4-tetrahydroquinoline-3-methanol 10 and 1, 2, 3, 5, 6, 10b-hexahydrobenzo [g] indolizine-6-methanol 34 are described. The aryl phosphonic acid 14, which can be used as a linker to a protein, is synthesised and coupled to the above alcohols. These haptens, when linked to a protein, are intended to generate antibodies able to catalyse cationic cyclisation reactions.