The Synthesis of Pyrrolizidines. VI. Stereochemical Correlation of 1-Methyl-and 1-Hydroxymethylpyrrolizidine Isomers with Certain Alkaloid Products1

NJ Leonard, DL Felley

文献索引：Leonard; Felley Journal of the American Chemical Society, 1949 , vol. 71, p. 1758 Journal of the American Chemical Society, 1949 , vol. 72, p. 2541

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被引用次数: 30

摘要

In the synthesis of 1-methylpyrrolizidine (I) starting with nitromethane and ethyl crotonate by a three-step method involving two Michael condensations followed by reductive cyclization, both asymmetric centers (carbons 1 and 8) have been established prior to the reduction