T-type calcium channel blockers: spiro-piperidine azetidines and azetidinones—optimization, design and synthesis

…, J Kieselgof, Z Tan, D Rindgen, T Bridal, X Zhou…

文献索引：Smith, Elizabeth M.; Sorota, Steve; Kim, Hyunjin M.; McKittrick, Brian A.; Nechuta, Terry L.; Bennett, Chad; Knutson, Chad; Burnett, Duane A.; Kieselgof, Jane; Tan, Zheng; Rindgen, Diane; Bridal, Terry; Zhou, Xiaoping; Jia, Yu-Ping; Dong, Zoe; Mullins, Debbie; Zhang, Xiaoping; Priestley, Tony; Correll, Craig C.; Tulshian, Deen; Czarniecki, Michael; Greenlee, William J. Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 15 p. 4602 - 4606

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被引用次数: 17

摘要

A series of spiro-azetidines and azetidinones has been evaluated as novel blockers of the T- type calcium channel (CaV3. 2) which is a new therapeutic target for the potential treatment of both inflammatory and neuropathic pain. Confirmation and optimization of the potency, ...