Analogs of 3-quinuclidinyl benzilate

…, WC Eckelman, DA Simms, EM Jagoda…

文献索引：Rzeszotarski, W. J.; Gibson, R. E.; Eckelman, W. C.; Simms, D. A.; Jagoda, E. M.; et al. Journal of Medicinal Chemistry, 1982 , vol. 25, # 9 p. 1103 - 1106

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被引用次数: 37

摘要

A number of analogues of 3-quinuclidinyl benzilate (QNB) have been synthesized and their affinities to muscarinic receptor from rat or dog ventricular muscle measured. We have determined that the muscarinic receptor can to a different degree accomodate either a halogen in the ortho, meta, or para position of one phenyl ring or the replacement of one phenyl ring with an alkyl group. Our in vitro competition studies show that the affinities lie ...