Molecules

In vitro anti-Candida activity of certain new 3-(1H-imidazol-1-yl) propan-1-one oxime esters

MI Attia, AS Zakaria, MS Almutairi, SW Ghoneim

文献索引：Attia, Mohamed I.; Zakaria, Azza S.; Almutairi, Maha S.; Ghoneim, Soraya W. Molecules, 2013 , vol. 18, # 10 p. 12208 - 12221

全文：HTML全文

被引用次数: 12

摘要

Abstract: Anti-Candida activities of certain new oximes 4a–d and their respective aromatic esters 5a–l are reported. The tested compounds 4a–d and 5a–l exhibited better anti- Candida profiles than fluconazole. Compound 5j, namely (E)-3-(1 H-imidazol-1-yl)-1- phenylpropan-1-one O-4-chlorobenzoyl oxime emerged as the most active congener, with a MIC value of 0.0054 µmol/mL being more potent than both fluconazole (MIC> 1.6325 µmol ...