Studies on Vitamin B1 and Related Compounds. CIX. A Novel Cleavage of Thiamin and Its Homologues by the Reaction with Aromatic Aldehydes

Y OKA, S KISHIMOTO, H HIRANO

文献索引：Oka,Y. et al. Chemical and Pharmaceutical Bulletin, 1970 , vol. 18, p. 527 - 533

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被引用次数: 15

摘要

A novel cleavage reaction of thiamin to give 4-amino-2, 5-dimethylpyrimidine (III) and 2- benzoyl-5-(2-hydroxyethyl)-4-methylthiazole (IV) has been discovered. The reaction involves the treatment of thiamin chloride hydrochloride (I) with two mole equivalents of triethylamine and an excess of benzaldehyde in methanol. The finding was further extended to the reactions of thiamin and its homologs with a variety of aromatic aldehydes to give ...