Total synthesis of mycophenolic acid

RL Danheiser, SK Gee, JJ Perez

文献索引：Danheiser,R.L.; Gee,S.K.; Perez,J.J. Journal of the American Chemical Society, 1986 ,  vol. 108, p. 806            

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被引用次数: 122

摘要

Abstract: A convergent aromatic annulation strategy based on the thermal combination of heterosubstituted acetylenes and cyclobutenones has been applied in an efficient total synthesis of the antitumor antibiotic mycophenolic acid. The key annulation components 3 and 4 are rapidly assembled by straightforward routes and then heated in benzene at 120 OC for 14 h. This annulation reaction generates the pentasubstituted aromatic ...