Novel dual inhibitors of 5-lipoxygenase and thromboxane A2 synthetase: synthesis and structure-activity relationships of 3-pyridylmethyl-substituted 2-amino-6- …
Much effort has been directed at investigating the relationship between inflammatory diseases and arachidonic acid metabolites, such as the leukotrienes (LTs), prostaglandins (PGs), and thromboxanes (TXs). lP4 During the past decade, it has become clear that these mediators play important roles in some inflammatory or allergic diseases, either acting alone or in combinati~ n.~,~ Extensive research has been undertaken to develop dual inhibitors ...
