Direct N-cyclopropylation of cyclic amides and azoles employing a cyclopropylbismuth reagent

…, M St-Onge, K Little, M Duplessis…

文献索引：Gagnon, Alexandre; St.-Onge, Miguel; Little, Kelly; Duplessis, Martin; Barabe, Francis Journal of the American Chemical Society, 2007 , vol. 129, # 1 p. 44 - 45

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被引用次数: 39

摘要

Cyclopropanes are commonly found in medicinal chemistry since they provide unique spatial and electronic features, combined with high metabolic stability in liver microsomes. Although many methods are found in the chemist's arsenal to connect a cyclopropyl group to a carbon atom, none exist that perform the direct transfer of this useful fragment onto the nitrogen of a heterocycle or an amide. Considering the importance of nitrogenated ...