Structure-activity relationships and pharmacokinetic analysis for a series of potent, systemically available biphenylsulfonamide matrix metalloproteinase inhibitors
PM O'Brien, DF Ortwine, AG Pavlovsky…
文献索引：Journal of Medicinal Chemistry, , vol. 43, # 2 p. 156 - 166
... Journal of Medicinal Chemistry. ... 3-6 The accumulation of evidence suggesting that upregulation of MMPs is involved in these, and other disease states, has led to a growing number of pharmaceutical companies attempting to design and develop orally active inhibitors that ...
