Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 8. Molecular dissections of carbocyclic 3-deazaadenosine as inhibitors of S- …

…, EK Dolence, BT Keller, U Patel-Thombre…

文献索引：Houston; Dolence; Keller; Patel-Thombre; Borchardt Journal of Medicinal Chemistry, 1985 , vol. 28, # 4 p. 467 - 471

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被引用次数: 31

摘要

14 84 95 15 11 12 16 12 50 a AdoHcy hydrolase activity was determined by using the procedure of Richards et d., 6 which involves measuring the hydrolysis of [2, 8-3H] AdoHcy to [2, 8-3H] adenosine and homocysteine. The assay includes adenosine deaminase, which converts [2, 8-* H]-adenosine to [2, 8-3H] inosine, and the [2, 8-sH] inosine is measured by scintillation spectrometry after separation on SP-sephadex-C-25. See Experimental ...