Total synthesis of tricyclic azaspirane derivatives of tyrosine: FR901483 and TAN1251C

M Ousmer, NA Braun, C Bavoux, M Perrin…

文献索引：Ousmer; Braun; Bavoux; Perrin; Ciufolini Journal of the American Chemical Society, 2001 , vol. 123, # 31 p. 7534 - 7538

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被引用次数: 108

摘要

A solution to the long-standing problem presented by the oxidative cyclization of a phenolic 3-arylpropionamide to a spirolactam has been developed in this laboratory via oxazoline chemistry. This research was motivated by our interest in some novel tricyclic azaspirane natural products formally derived from tyrosine, such as FR901483 and TAN1251C. In this paper, we disclose full details of the total synthesis of these substances.