Group IVA organometallic reagents. 2. Enantiomeric purity determination of 1, 2-diols through NMR spectroscopy without chiral auxiliaries

C Luchinat, S Roelens

文献索引：Luchinat,C.; Roelens,S. Journal of the American Chemical Society, 1986 , vol. 108, p. 4873

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被引用次数: 33

摘要

Abstract: The use of optically active chiral auxiliaries for enantiomeric purity determinations by NMR can be avoided if the appropriate conditions for the “selfdiscrimination” of enantiomers are met. Molecular aggregation under fast-exchange conditions is shown to potentially render selfdiscriminating chiral molecules in nonracemic mixtures through the generation of diastereomeric relationships among groups. This phenomenon should not a ...