5'-Azido-. DELTA. 8-THC: a novel photoaffinity label for the cannabinoid receptor

A Charalambous, G Yan, DB Houston…

文献索引：Charalambous, Avgui; Yan, Guo; Houston, Devin B.; Howlett, Allyn C.; Compton, David R.; et al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 16 p. 3076 - 3079

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被引用次数: 62

摘要

Although the pharmacological and biochemical properties of cannabinoids have been studied extensively? their molecular mechanism of action is not yet well understood. The high lipophilicit? of these molecules, together with their reported effects on the thermotropic4 $ and dynamic? properties of model and natural membranes, suggests that at least some of the cannabinoid actions could be related to their abilities to interact with the lipid ...