Compounds were tested on the three different forms of PDE isolated from bovine aorta. 6 The first form hydrolyzed preferentially cGMP and was activated 6-15-fold by calmodulin (CaM); it was named CaM-PDE. The second form hydrolyzed cGMP with a high degree of selectivity and was insensitive to CaM and cGMP; it was called cGMP-PDE. The third peak hydrolyzed preferentially cAMP and was not stimulated by CaM; it was named CAMP-PDE ...
