Several hydroxybisphosphonate benzyl esters have been synthesized for study. The effect of the benzyl substituent on the acidic hydrolysis of the phosphonic esters has also been studied. ... Keywords: Hydroxybisphosphonate; p-substituted benzyl esters; acidic hydrolysis ... Hydroxybisphosphonates are pyrophosphate analogs in which the oxygen bridge has been replaced by carbon, and diverse side chains have gener- ated a large family of ...
