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Antiallergic and cytoprotective activity of new N-phenylbenzamido acid derivatives.

F Makovec, W Peris, L Revel, R Giovanetti…

文献索引:Makovec; Peris; Revel; Giovanetti; Redaelli; Rovati Journal of Medicinal Chemistry, 1992 , vol. 35, # 20 p. 3633 - 3640

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被引用次数: 15

摘要

A series of new N-phenylbenzamido acid derivatives was synthesized and evaluated for their ability to inhibit the IgE-mediated passive cutaneous anaphylaxis in the rat (PCA), as well as for their capacity to inhibit gastric mucosal damage induced by the oral administration of absolute alcohol in the rat. Some of these new derivatives exhibit potent antiallergic and cytoprotective activity, 20-80 times higher than that of the reference, ...