Substituent-directing effects in the homolytic acylation of pyrazine derivatives

Y Houminer, EW Southwick…

文献索引：Houminer, Y.; Southwick, E. W.; Williams, D. L. Journal of Organic Chemistry, 1989 , vol. 54, # 3 p. 640 - 643

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被引用次数: 18

摘要

The substitution patterns in all products (4-1 1) were easily determined by measuring the coupling constants of the pyrazine ring protons in the lH NMR spectra of these compound^.^ All 2, 3-disubstituted pyrazines have J 1 2.5 Hz, whereas 2, 6-and 2, 5-disubstituted pyrazines have JI 0.1 Hz and J-1.5 Hz, respectively. Nevertheless, in one case we have also established the substitution pattern by carrying out a number of chemical transformations. ...