Hepatoprotective pyrrole derivatives of Lycium chinense fruits

YW Chin, SW Lim, SH Kim, DY Shin, YG Suh…

文献索引：Chin, Young-Won; Lim, Song Won; Kim, Seok-Ho; Shin, Dong-Yun; Suh, Young-Ger; Kim, Yang-Bae; Kim, Young Choong; Kim, Jinwoong Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 1 p. 79 - 81

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被引用次数: 97

摘要

As a part of our search for hepatoprotective compounds from Lycium chinense fruits, three new pyrrole derivatives (1–3) were isolated. These compounds and a related synthetic methylated compound (4) were evaluated for their biological activity and structure–activity relationship, and compounds 1 and 2 showed hepatoprotective effects comparable to silybin at the concentration of 0.1 μM (64.4 and 65.8%, respectively).