Radioiodinated dechloro-4-iodofenofibrate: a hydrophobic model drug for molecular imaging studies

S Breyer, A Semmler, T Miller, A Hill, S Geissler…

文献索引：Breyer, Sandra; Semmler, Angelika; Miller, Tobias; Hill, Alexandra; Geissler, Simon; Haberkorn, Uwe; Mier, Walter International Journal of Pharmaceutics, 2012 , vol. 431, # 1-2 p. 78 - 83

全文：HTML全文

被引用次数: 9

摘要

Radiolabeling is a valuable option for tracking drug molecules in biodistribution experiments. In the development of innovative drug delivery systems the influence of the pharmaceutical formulation on the drugs' pharmacokinetics has to be investigated. The hypolipidemic agent fenofibrate is an ideal model drug for testing the performance of drug delivery systems designed for poorly soluble compounds. Herein, we report a de novo ...