Tetrahedron letters

Efficient regioselective synthesis of enantiomerically pure 4-hydroxymethyl-Δ 2-thiazoline

F Almqvist, D Guillaume, SJ Hultgren, GR Marshall

文献索引：Almqvist, Fredrik; Guillaume, Dom; Hultgren, Scott J.; Marshall, Garland R. Tetrahedron Letters, 1998 , vol. 39, # 16 p. 2293 - 2294

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被引用次数: 13

摘要

To a solution of 1,2-aminothiol and Na 2 CO 3 in a minimum volume of water, a previously prepared solution of acetic anhydride (1.05 equiv.) and formic acid (1.2 equiv.) was added. The pH of the solution was kept alkaline by addition of solid Na 2 CO 3 and the solution was stirred for 60 min. The remaining solids were removed by filtration and the cake washed three times with CHCl 3 . The organic phase was neutralized (6N HCl) and concentrated. The residue was ...