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A New Regioselective Synthesis of 1, 2, 5-Trisubstituted 1 H-Imidazoles and Its Application to the Development of Eprosartan

SC Shilcrat, MK Mokhallalati…

文献索引:Journal of Organic Chemistry, , vol. 62, # 24 p. 8449 - 8454

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被引用次数: 62

摘要

... The Journal of Organic ... A variety of bases, both organic and inorganic, were tested in the reaction. ... One mechanism that would explain the high regioselectivity of this reaction is shown in Scheme 2. The unsubstituted nitrogen (an imino nitrogen except for 12i, j) adds in a Michael ...