Total synthesis of rapamycin via a novel titanium-mediated aldol macrocyclization reaction

…, D Yohannes, SJ Danishefsky

文献索引：Hayward; Yohannes; Danishefsky Journal of the American Chemical Society, 1993 , vol. 115, # 20 p. 9345 - 9346

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被引用次数: 159

摘要

The advent of the two" tricarbonyl" macrolactam-macrolactone immunosuppressive agents rapamycin (l) l, z and FK-5063 has provided exciting multidisciplinary scientific challenges. 4 Indeed, by drawing upon the powerful resources of chemistry (both synthetic and tructural)~- ~ in conjunction with those of molecular and cell biology, Schreiber and associates are in the process of defining the mechanisms of action of these drugs in striking detaiL7 Tota1*, ...