Synthesis, structure–activity relationships and biological evaluation of barbigerone analogues as anti-proliferative and anti-angiogenesis agents

…, Z Yang, L Ma, A Peng, M Xiang, Y Wei, L Chen

文献索引：Wang, Guangcheng; Wang, Fang; Cao, Dong; Liu, Yibin; Zhang, Ronghong; Ye, Haoyu; Li, Xiuxia; He, Lin; Yang, Zhuang; Ma, Liang; Peng, Aihua; Xiang, Mingli; Wei, Yuquan; Chen, Lijuan Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 14 p. 3158 - 3163

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被引用次数: 3

摘要

Abstract A series of barbigerone analogues (7a–7w, 13a–13x) were designed, synthesized and biologically evaluated for their anti-proliferative and anti-angiogenic activities. Among these compounds, compound 13a exhibited the most potent inhibitory effect on the proliferation of HUVECs, HepG2, A375, U251, B16, and HCT116 cells (IC 50= 3.80, 0.28, 1.58, 3.50, 1.09 and 0.68 μM, respectively). Compound 13a inhibited the angiogenesis in ...