Some Analogs of 4-(2', 4'-Difluorobiphenyl-4-yl)-2-methyl-4-oxobutanoic Acid: Synthesis and Antiinflammatory Activity

M Kuchař, V Vosátka, M Poppová…

文献索引：Kuchar, Miroslav; Vosatka, Vaclav; Poppova, Marie; Knezova, Eva; Panajotovova, Vladimira; et al. Collection of Czechoslovak Chemical Communications, 1995 , vol. 60, # 6 p. 1026 - 1033

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被引用次数: 7

摘要

Abstract Analogs of 4-(2', 4'-difluorobiphenyl-4-yl)-2-methyl-4-oxobutanoic acid (I, flobufen), containing a double bond (II, IV, V, VII, VIII) or a methyl group in position 3 (VI) were prepared. Their antiinflammatory activity was evaluated and compared with that of flobufen. None of the mentioned analogs reached the activity of the standard. Isomerization of the unsaturated derivatives is connected with a shift of the double bond, ZE transformation or ...